MI-2-2 hydrochloride ( —— )

Catalog No. M17067 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MI-2-2 hydrochloride
Note

Research use only, not for human use.
Brief Description

MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
Description

MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

--
Formula Weight

451.96
Molecular Formula

C17H21ClF3N5S2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine hydrochloride

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.

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